"Computer louse" is an old term for a computer bug, which has recently become more popular again.

In early computer programming

Shortly after computers started to manifest around the world, people figured out that they needed to program them in order to get them to do stuff. Early computer programming was done with punch cards, and it was very easy to fuck up the punch cards and get the wrong output from the computer. People called this a "computer louse" because the operator had done a lousy job of punching the cards right.

The term was generalised to "bug" by Grace Hopper in 1947 after she found a moth in her computer causing a problem with it. Moths aren't lice, but they're still kinda bugs, so it was a better word. "Bug" became the popular term, and "louse" fell out of use.

In modern computing

Because "computer louse" is an old term, it's becoming more popular to use by nostalgiapilled zoomers. They don't actually know what they're talking about though so they're using the word all wrong, ewwwwwww.

Nowadays, a computer louse is a louse that lives in a computer. Because nostalgiapilled zoomers don't know anything about how the world works, they don't realise that we had the word "bug" for this and it worked perfectly fine. Oh well.